HPV Oral Prevalence in Scotland (HOPSCOTCH) Feasibility Study
The HOPSCOTCH Study investigated the feasibility of undertaking an epidemiology of the prevalence, incidence, and determinants of oral HPV infection in dental practice settings in Scotland.
Funding
HOPSCOTCH was funded from the Scottish Government Chief Scientist Office (CSO) grant no. CZH/4/917
Results
By the study end we recruited 402/500 patients (80% of target), having reached recruitment targets at three of the seven sites.
For a summary of the project results please see CSO focus on Research: http://www.cso.scot.nhs.uk/wp-content/uploads/CZH_4_917.pdf
The full paper can be accessed at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165847
Study Overview & Objectives
This 20 month study tested the feasibility of undertaking a full population investigation into the prevalence, incidence, and persistence of oral HPV in Scotland via dental settings. The study began in July 2013 and participant recruitment commenced in November 2013. We aimed to recruit 500 participants across seven dental settings from two NHS Health Boards – Tayside and Greater Glasgow & Clyde. Participants were screened from patient lists and invited to take part in the study. Following positive consent at the time of their dental appointment, participants provided an oral gargle/rinse sample and completed an in-depth questionnaire including questions on socio-demographics and lifestyle behaviours and a detailed sexual history questionnaire.
The Objectives of our feasibility study were to examine:
- the suitability of different dental settings, including different models of recruitment (research nurse vs. dental nurse) and follow-up (study appointments, dental appointments, and postal);
- subject participation and consent;
- data and sample collection/ handling - including lifestyle/ sexual history questionnaire, and oral gargle/rinse;
- record linkage to national health datasets;
- sample validation for HPV detection assay.
The findings, primarily, will be used to inform the future shape of a larger population based study, which has the ultimate aim of assessing the prevalence, incidence, transmission and determinants of oral HPV infection in Scotland. This investigation also is in the context of the HPV vaccination programme established in 2008 for females aged 12-13 years, and aims to assess the vaccine’s impact on oral HPV in females and “herd immunity” in males.
Collaborators
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University of Dundee |
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University of Edinburgh |
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University of Glasgow |
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University of Strathclyde |
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Scottish Dental PBRN |
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Throat Cancer Foundation |
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NHS Education for Scotland |
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NHS Greater Glasgow & Clyde |
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NHS Lothian |
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NHS Tayside |
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Scottish HPV Investigators Network |
Steering Group
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Dr David Conway (PI) |
Clinical Senior Lecturer University of Glasgow Dental School, 378 Sauchiehall Street |
Tel: 0141 211 9750 |
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Professor Jeremy Bagg, |
Professor of Clinical Microbiology & Head of School University of Glasgow Dental School |
Tel: 0141 211 9741 PA: 0141 211 9701
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Ms Lucy Dunbar (Chair) |
Oral Health Collaborative Research Administrator University of Glasgow Dental School, 378 Sauchiehall Street |
Tel: 0141 211 9764 |
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Dr Heather Gray |
HOPSCOTCH Project Manager University of Glasgow Dental School, 378 Sauchiehall Street |
Tel: 0141 211 9746 |
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Dr Lisa McDaid |
Programme Leader (Track) Sexual Health MRC/CSO Social & Public Health Sciences Unit |
Tel: 0141 357 7568
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Sharon Kean |
Director of Information Systems R1111 Level 11 |
Tel: 0141 330 3266 |
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Dr Andrew Winter |
Consultant in Sexual Health and HIV Joint Clinical Director Sandyford Initiative Sandyford Sexual Health Services |
Tel: 0141 211 1087 |
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Professor Chris Robertson
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Professor of Statistics |
Tel: 0141 548 3215
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Professor Jan Clarkson |
Co-Director, Dental Health Services Research Unit (DHSRU) |
JC direct dial: Tel: 01382 740990 PA Alana Gowans Tel: 01382 740961 |
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Dr Linda Young |
Associate Researcher Research Manager for NES’ Scottish Dental Clinical Effectiveness knowledge translation (TRiaDS) & practice based research network (SDPBRN) programmes |
Tel: 01382 420154 |
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Professor Heather Cubie
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HPV Research Group and Scottish HPV Investigators Network (SHINe) MRC University of Edinburgh Centre for Reproductive Health Queen’s Medical Research Institute |
Heather.Cubie@luht.scot.nhs.uk Tel: 0131 242 6625
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Dr Christine Campbell |
Centre for Population Health Sciences The University of Edinburgh |
Tel: 0131 650 9252 |
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Dr Kate Cuschieri, PhD
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Director Scottish HPV Reference Laboratory |
Kate.Cuschieri@luht.scot.nhs.uk Tel: 0131 242 6039
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Dr Ramya Bhatia
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Research Programme Manager HPV Research Group |
Tel: 0131 242 6625
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Dr Fergus Daly |
Biostatistics Team Lead Frontier Science (Scotland) Ltd |
fergusd@frontier-science.co.uk Tel: 01540 651012
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Dr Kevin Pollock
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Epidemiologist, Vaccine Preventable Diseases |
Tel: 0141 300 1913
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Mr Jamie Rae |
Founder & CEO of the Throat Cancer Foundation
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Project Contacts
Chief Investigator
Dr David Conway - david.conway@glasgow.ac.uk